MovDisordV3, Main, Exploration, bibRecord, 003428

Fulminant Lewy body disease

Identifieur interne : 003428 ( Main/Exploration ); précédent : 003427; suivant : 003429

Fulminant Lewy body disease

Auteurs : Isabelle Momjian-Mayor [Suisse] ; Gian Paolo Pizzolato [Suisse] ; Karim Burkhardt [Suisse] ; Theodor Landis [Suisse] ; Alessandra Coeytaux [Suisse] ; Pierre R. Burkhard [Suisse]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-10.

RBID : ISTEX:30B3B414DC73EA5DBB0EA2A45B9A32BB88740277

English descriptors

KwdEn :
- 14-3-3 Proteins (analysis), Aged, Brain (pathology), Creutzfeldt-Jakob Syndrome (diagnosis), Creutzfeldt-Jakob Syndrome (pathology), Diagnosis, Differential, Disease Progression, Fatal Outcome, Humans, Lewy Bodies (pathology), Lewy Body Disease (diagnosis), Lewy Body Disease (pathology), Lewy body, Male, Neurologic Examination, Neuropsychological Tests, Parkinson Disease (diagnosis), Parkinson Disease (pathology), Parkinson's disease, dementia.
MESH :
- chemical , analysis : 14-3-3 Proteins.
- diagnosis : Creutzfeldt-Jakob Syndrome, Lewy Body Disease, Parkinson Disease.
- pathology : Brain, Creutzfeldt-Jakob Syndrome, Lewy Bodies, Lewy Body Disease, Parkinson Disease.
- Aged, Diagnosis, Differential, Disease Progression, Fatal Outcome, Humans, Male, Neurologic Examination, Neuropsychological Tests.

Abstract

The clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of DLB. At autopsy, numerous Lewy bodies and Lewy neurites were found in several areas of the brainstem, the limbic system, and the neocortex, consistent with pure DLB. This case demonstrates that Lewy body disease may exhibit a dramatic course without any coexisting pathology and exemplifies that PD, PDD, and DLB may sometimes represent sequential, yet overlapping, phenotypes of a same clinicopathological entity. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/30B3B414DC73EA5DBB0EA2A45B9A32BB88740277/fulltext/pdf

DOI: 10.1002/mds.21034

Affiliations:

Suisse

Le document en format XML

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<author><name sortKey="Pizzolato, Gian Paolo" sort="Pizzolato, Gian Paolo" uniqKey="Pizzolato G" first="Gian Paolo" last="Pizzolato">Gian Paolo Pizzolato</name>
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<front><div type="abstract" xml:lang="en">The clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of DLB. At autopsy, numerous Lewy bodies and Lewy neurites were found in several areas of the brainstem, the limbic system, and the neocortex, consistent with pure DLB. This case demonstrates that Lewy body disease may exhibit a dramatic course without any coexisting pathology and exemplifies that PD, PDD, and DLB may sometimes represent sequential, yet overlapping, phenotypes of a same clinicopathological entity. © 2006 Movement Disorder Society</div>
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Movement Disorders (revue)

Fulminant Lewy body disease

Fulminant Lewy body disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.